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NIC BIOLABELS
EQUIPMENT AND INFRASTRUCTURE

The  Biolabels   Unit  is  housed  within  5  main  areas;   The   Main  Nanotechnology   Synthesis  Lab (MinNanoGold™),   The  POC  developmental  lab  (MinDiagnostics™),   The Peptide  Synthesis  Lab (MinPeptides™), The Tissue Culture Lab (NicTox™) and the ISO level 5 clean room, POC production facility (MinDiagnostics™).  Each facility contributes toward the vision and mission of the Biolabels Unit and the NIC as a whole.

MinDiagnostics™

BIODOT AUTOMATED DISPENSER (RR4510)

The RR120 is a modular, in-line processing  system that includes, web feed, dispensing with web tracking, vision inspection/bad part marking, impregnation, drying  and take-up   in   a   controlled   humidity   environment.  The system  provides  processing of webs  from 5 - 120 mm widths.

BIODOT AUTOMATED LAMINATOR (LM6000)

The   LM6000   Continuous    Laminating    System   is    a modular  design to  accommodate various  numbers and types of materials.  Each material is fed,  from adjustable spindles,  through  guides and  under a pressure  capstan roller, to assure complete adhesion to the plastic support backing.

BIODOT GUILOTINE CUTTER
(CM4000)

The CM4000 Guillotine Cutter is a robust, fully automatic workstation   that  provides  high  quality  precision  cuts. Blades   are  made  from   hardened   steel   and   specially coated  to improve  ejection of cut strips and  reduce glue build up.

MinPeptides™ and NicTox™

SYMPHONY PEPTIDE SYNTHESIZER

The Symphony® is a 12-channel peptide synthesizer, with production from 0.005 - 7.5mmol.  It is versatile,  has fast  multi-plex  operation,  with  low  coupling  cost, variable    synthetic    scales,   automated cleavage and customisable protocols.

FREEZE DRYER


Freeze-drying  is a  dehydration  process, typically used  to  preserve  a  perishable material   or   make   the   material   more convenient for transport.   Freeze-drying works by freezing the  material and then reducing   the  surrounding   pressure  to allow  the frozen water in the material to sublimate  directly  from  the solid phase to the gas phase.

PREP-HIGH PRESSURE LIQUID CHROMATOGRAPHY (HPLC)

It   is   used   to   separate,    identify    and quantify   components   in   a   mixture. It relies  on  pumps  to  pass  a  pressurized solvent, containing  the  sample  mixture, through   a   column   filled   with   a   solid adsorbent material.  Each  component in the sample  interacts  slightly  differently with the  adsorbent  material,  leading to the separation of the components.

xCELLigence RTCA MP SYSTEM

The xCELLigence Real Time Cell Analysis MultiPlate instrument uses non-invasive electrical    impedance     monitoring      to quantify   cell   proliferation,  morphology change   and   attachment   quality   in   a label-free, real-time manner.

MinNanoGold™

HIGH RESOLUTION SCANNING ELECTRON MICROSCOPY (HRSEM)

The   FEI  Nova   Nano-SEM  200   Field  Emission  HRSEM enables    both   high   and    very    low   kV    imaging   and analytical   capabilities  of  specimens  in  and  below  lens configurations. It is equipped with an Everhardt Thornley Detector (EDT),  backscattered electron  detector (BSED), through-the-lens    detector   (TLD)   for   high    resolution imaging   and  a   X-ray  spectrometer   (EDXS)  for   X-ray analysis.

TRANSMISSION ELECTRON MICROSCOPY (TEM)

The  NIC  has  a  JEOL  JEM-2100F,  Field  Emission  Gun (200kV), Transmission  Electron  Microscope  (FEG-TEM) capable   of  providing   high   spatial   resolution,   atomic imaging   and  micro-   and   nano-structure   analysis   of materials.

ATOMIC FORCE MICROSCOPY (AFM)

The   NIC   owns   both   a   Nanoscope  and   Enviroscope multimode  Atomic  Force  Microscope.   The  multi-mode AFMs use  both contact  and tapping  modes  to analyse samples, with nanometer  range resolution.  The samples can    be   analysed    under   high    vacuum   and   various conditions,  like   temperature  can   be  altered  whilst the analysis is performed.

NIR/UV-Vis SPECTROSCOPY

A spectrophotometer  is  an instrument  which measures the reflection or absorbance characteristics of a sample. Here the  absorbance can  be captured  in the  ultraviolet, visible   and    near-infrared    wavelength    ranges    (300 -
3200 nm).

PERKIN ELMER 400R RAMAN SPECTROMETER

It    is   a   vibrational   technique   for   identification   and analysis of  molecular  species.  The science is based on the detection and processing of the  scattered radiation produced  from  a  molecule  when  it  is irradiated with a monochromatic laser light.

MALVERN ZETA SIZER

The   Zetasizer  Nano   Z  system   is   dedicated  to  the measurement   of  zeta  potential  and  electrophoretic mobility of colloids and nanoparticles, in aqueous and non-aqueous dispersions,  using Laser  Doppler Micro-Electrophoresis.

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