DST/MINTEK

Nanotechnology Innovation Centre

Innovation through nanotechnology

Therapeutics Platform

This platform focuses on research and development of functionalised metal nanoparticle systems for therapeutics and targeted drug delivery.

System Development:

The Biolabels unit has developed a range of metal nanoparticles for biological and pharmaceutical applications (e.g. Gold, silver, etc,)  These nanoparticles are produced by the Unit as semi-commercial products ranging from 2 nm to 10 nm in size.  Nanomaterials produced by the Unit are classified as colloids, monolayer protected clusters (MPCs) and bioconjugate systems.

Colloids:  

These are produced as important building blocks for nanotechnological applications.

Monolayer Protected Clusters (MPCs):

MPCs are produced specifically to address advanced application by attaching specific functionalized ligands of choice on the nanoparticle core.  Biocompatible functional MPCs containing various functional groups such as carboxyl, amine, azide, biotin, nitrilotriacetic acid (NTA) etc.  are produced.

Bioconjugates:

Bioconjugates are produced by attaching specific biomolecular functionality or biomargers (proteins, sugars, peptides, enzymes, antibodies, etc.) on the surface of MPCs.  They are engineered addressing key issues, such as stability, biocompatibility etc. The nanobioconjugate systems are utilized in various diagnostic and therapeutic applications.  Custom conjugation is also offered.


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The diagnostic platform focuses on the design and development of rapid diagnostic tests for human and animal diseases and labeling reagents for in vivo imaging.





Optical Diagnostics.

  • The Unit develops a variety of lateral flow devices for the detection of human as well as animal diseases that plague the African continent and beyond.
  • The lateral flow tests focus on the detection of antibodies/antigens in the test sample (sera, blood, saliva, urine) using biomarker functionalized gold nanoparticles.

Diagnostics Platform

Development of nano-technology based labeling reagents to acurately diagnose, manage and treat diseases.

Applications

The labeling reagesnt developed in the Unit are used by our collaborators for research in:

  • Diabetes diagnostics

Infrastructures

The Unit has world class equipment for synthesis, characterisation and fabrication of nanomaterials and nano-enabled devices.

Nanosight LM-20




Plate reader and washer




Zeta Sizer























In Vivo Imaging

Vision

To become a leading innovator in the field of nanomedicine.

To develop expertise in the field of nanomedicine or nanotechnology in South Africa.

Objective

To develop functionalized metal nanoparticles (or tools) for in-vivo imaging and therapeutic applications.

To design and develop nanotechnology-based point-of-care (POC) diagnostics


Research Focus Area

The Biolabels Development Unit focuses on developing nanomaterials-based systems for applications in Therapeutics and Diagnostics.

Therapeutics Applications

The nano-bioconjugates systems developed in the therapeutics platform are used for applications in

CANCER RESEARCH

OBESITY RESEARCH

HIV RESEARCH

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General Contact Info

Mintek, SA, Johannesburg

GPS: -26,5º25.77;  -27,58º45.27 E

Private Bag X3015

Randburg

South Africa

Tel:  +27 11 709 4111

Fax: +27 11 793 2413

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